MOTS-c

MOTS-c: A mitochondrial-derived peptide investigated in cellular energy regulation.

What is it?

A mitochondrial-derived peptide investigated in cellular energy regulation.

How it is studied

Research models connect MOTS-c to energy regulation and insulin-related signalling, linking mitochondrial biology with wider cellular responses.

What the evidence says

An early human trial investigated CB4211, a modified analogue. That is a different molecule from native MOTS-c, so its trial is not direct clinical evidence for this compound.

What remains uncertain

Much of the native-peptide evidence is preclinical. Exercise-related findings and an analogue’s clinical programme do not establish human efficacy or long-term safety for MOTS-c.

Sources & scope

CB4211 analogue trial, NCT03998514

For in-vitro laboratory research only. Not for human or veterinary use.